The Neuro Tardigrade Project
Establishing tardigrades as a new model system for systems neuroscience
It is a little known fact that Sydney Brenner, who established the celebrated C. elegans model system, leading to countless biological discoveries and biotechnological advances, briefly considered tardigrades for this role. We are taking up this challenge, building on the extensive work in other model organisms, to develop a set of methods which will allow scientists to study these animals in full neuroscientific detail.
About the Neuro Tardigrade Project
Mesoscale Systems Neuroscience
Establishing a new animal model system used to absorb the entire careers of many scientists. The advent of high efficacy genomic engineering and other technologies has made the development of new animal model systems much more attainable.
And we learn so much from every new model organism.
Sub-projects
We've sketched out the components of what we think is needed to do great systems neuroscience - the study of how nervous systems produce effective organism behavior. These sub-projects are intended to enable researchers to coalesce around focused, clear milestones. There are many other projects worth considering -- feel free to suggest.
Indicators, Precise Mutations
If we can knock GCaMP into neurons, we can image the heck out of them. If we can knock out genes, we can pursue classical genetic loss of function studies.
Whole brain calcium imaging, fixed and free moving
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Calcium Imaging - Fixed and Free Moving
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